I don’t use Applications Manager, but as I understand it, it is build on top of the Automation Engine, and uses the same scripting language.
With Automation Engine v11 or later, you can simply create an external interpreter for Python. See the example here:
:REGISTER_VARIABLE — practical examples with Bash, Perl, Python, Ruby, and PowerShell
With earlier versions, it is possible to define a single external interpreter (e.g., Python) for each Windows agent. This means that all Interpreter-type Windows jobs that run on that agent will use that interpreter.