DX Application Performance Management

I am getting this error too.

5/02/12 02:55:48.286 AM EDT [INFO] [main] [Manager] The Introscope Enterprise Manager is set to run in StandAlone mode.
5/02/12 02:55:48.301 AM EDT [INFO] [main] [Manager] IPv6 protocol is detected on Windows Operating System. Java New IO is disabled
5/02/12 02:55:48.317 AM EDT [INFO] [main] [Manager] Starting server...
5/02/12 02:55:49.520 AM EDT [INFO] [main] [Manager.Authentication] Introscope WebView connections are enabled
5/02/12 02:55:49.520 AM EDT [INFO] [main] [Manager.Authentication] Introscope WebView connections will be assigned the name "WilyWebView"
5/02/12 02:55:49.630 AM EDT [INFO] [main] [Manager.Authentication] Configured the Manager of Managers user using private key internal/server/EM.private
5/02/12 02:55:49.989 AM EDT [ERROR] [main] [Manager] The EM failed to start. Local Users and Groups realm is misconfigured. Error using new settings for Realm: XMLFileManager.CantDeleteFile
5/02/12 02:55:50.005 AM EDT [INFO] [main] [Manager] Shutting down the Isengard server
5/02/12 02:55:50.020 AM EDT [INFO] [main] [Manager] Orderly shutdown complete.

I already have IPv6 disabled but i don't know why it is still being detected.

I have installed:
Enterprise Manager Release 9.1.0.0 (Build 581006)
Windows Server 2008 R2 Enterprise

Any help is appreciated.
Thanks.

have you tried disabling IPV6 and then trying it out .. use the registry fix to disable IPV6 .. search google for "how to disable IPV6 in windows 2008" and you should find it ...