I am getting this error too.
5/02/12 02:55:48.286 AM EDT [INFO] [main] [Manager] The Introscope Enterprise Manager is set to run in StandAlone mode.
5/02/12 02:55:48.301 AM EDT [INFO] [main] [Manager] IPv6 protocol is detected on Windows Operating System. Java New IO is disabled
5/02/12 02:55:48.317 AM EDT [INFO] [main] [Manager] Starting server...
5/02/12 02:55:49.520 AM EDT [INFO] [main] [Manager.Authentication] Introscope WebView connections are enabled
5/02/12 02:55:49.520 AM EDT [INFO] [main] [Manager.Authentication] Introscope WebView connections will be assigned the name "WilyWebView"
5/02/12 02:55:49.630 AM EDT [INFO] [main] [Manager.Authentication] Configured the Manager of Managers user using private key internal/server/EM.private
5/02/12 02:55:49.989 AM EDT [ERROR] [main] [Manager] The EM failed to start. Local Users and Groups realm is misconfigured. Error using new settings for Realm: XMLFileManager.CantDeleteFile
5/02/12 02:55:50.005 AM EDT [INFO] [main] [Manager] Shutting down the Isengard server
5/02/12 02:55:50.020 AM EDT [INFO] [main] [Manager] Orderly shutdown complete.
I already have IPv6 disabled but i don't know why it is still being detected.
I have installed:
Enterprise Manager Release 9.1.0.0 (Build 581006)
Windows Server 2008 R2 Enterprise
Any help is appreciated.
Thanks.