I shouldn't think altering those settings will cause any issues for you. For QoS, it is determined more by demands of the business rather than the DB. For example SLA calculations. Of course, if you store a lot of data in your raw tables, their size will grow, their maintenance operation durations will grow, etc. Still, I shouldn't think there's an issue there. I'm keeping a year's worth of raw data.
For nas it's just pretty much about the DB size, I'd say. The transaction db and the alarm db are on the same server with nas, so those will grow and if your alarm volumes are high, I guess it might impact things. Don't know if there's any best practices regarding that. There's scarcely any 'best practices' with UIM really..
Also noteworthy, in data_engine configuration you can also configure threshold for the dn tables (daily average). This is not in the IM gui and if I remember correctly, also not in the AC gui.
-jon