Its really going to depend more on what your application exposes.
First I would disable autoprobe and restart and see if the app runs faster. If it does, then you would proceed to figure out what part(s) of the instrumentation are causing a slow down. If it still runs slow, then its not our instrumentation and the issue would be in your app somewhere.
So if it is our instrumentation, you could start by disabling Socket, UDP and Network tracing. You could also disable sqlagent tracing. Deep inheritance, appmap, leakhunter and changedetector are others you can turn off. These are our heaviest hitters.