Yes, you can do that using either the fixed_default section of the CFX file, or also using the "custom" section of CDM and write a regex like "[A-Z]:/\" to get all the drives monitored. As you prefer!
Keep in mind though that the fixed_default section is evaluated to instantiate one section per detected drive when a drive is detected only, ie. if your drive has already been detected and you change parameters in the fixed_default section afterwards, you'll have to remove the disk from the configuration and let CDM discover it again.