Officially, Automic supports Agents that is on the same version or one version back.
V8 Agent + AE v9 = supported
V9 Agent + AE v10 = supported
The Agent (can be higher) than the AE (but it should not be a higher Major version).
So if AE is V10 SP5 - The Agent should NOT be on a V11 agent. It can be a V10 SP8 etc agent.
V10.0.8 + AE v10.0.1 = supported
V11.1 + AE V10.0.8 = not supported
Note: lower version "may" work in some configuration but it won't be supported by Automic Support.