Thank you Ian for the info. I found case 21536278. L2 provided you with a new wrapper.exe and this was permanently fixed in 4.2 SP1 at the time.
Paul, what version of Process Automation are you on? If before 4.2 SP1, you will need to upgrade. If a later version of Process Automation, it may be a recurrence of this issue where the wrapper.exe config file does not maintain the system PATH.
Review c2oagtsvcw.conf (This is on the agent at C:\Program Files\CA\PAM Agent\PAMAgent) and confirm
set.PATH=%PATH%;%SystemRoot%System32
If you continue to have an issue, open a new case with support. Thank you.